Amniotic Fluid Chromosome Analysis Testing Indications for Amniotic Fluid Chromosomal Analysis
- Abnormal NIPT / Cell-free DNA
- Advanced maternal age (>35 years of age)
- Previous pregnancy with chromosomal abnormality
- Recurrent spontaneous miscarriage
- Family history of a chromosomal abnormality
- Abnormal maternal serum screening results
- Abnormal ultrasound findings
Specimen Requirements
15-20 ml amniotic fluid (less if early amniocentesis)
Collection Procedure
Discard the first 2 ml of fluid to reduce the risk of maternal cell contamination. Aseptically transfer the specimen into sterile plastic conical tubes labeled with patient’s name and date of birth. A completed test requisition form must be included with every sample. A transport kit is available upon request. To learn more about the Amniocentesis lab testing please call us today.
Specimen Container
Sterile 15 ml screw-cap container
Methodology
In situ culturing of amniocytes to identify both numerical and structural chromosome abnormalities
Transport Temperature
Room temperature (DO NOT refrigerate, freeze or centrifuge)
Causes for Rejection
Frozen specimen, excessive amounts of blood, inappropriate container
Turnaround Time
5-10 days